Inter start Lautaro Martinez, Francesco Pio Esposito and Hakan Calhanoglu for this tricky trip to Cagliari, where Daniel Maldini and Harry Winks provide creativity.
It kicks off at the Unipol Domus at 19.45 UK time (20.45 CEST).
The Nerazzurri won the domestic double last season of Scudetto and Coppa Italia, so go into this term as the favourites to keep dominating Italian football.
There have been new signings, above all Djed Spence, John Stones and Curtis Jones, but they are being gradually worked into the team.
Cristian Chivu still makes changes, bringing in Benjamin Pavard, Petar Sucic and Luis Henrique for Yann Bisseck, Piotr Zielinski and Andy Diouf after the 4-1 win over Monza.
Lautaro Martinez leads the attack with Pio Esposito, as Marcus Thuram is still not fully fit after the World Cup with France.
Cagliari had a surprisingly strong start to their campaign, securing a 1-0 victory away to Parma that could eventually be decisive to guarantee safety.
Yael Trepy was released from hospital 10 days after he nearly drowned in a swimming pool, with his teammates dedicating the winning goal to him last week.
Riyad Idrissi is a long-term absentee, but defender Yerry Mina is also ruled out by a muscular issue in defence.
Former Leeds United midfielder Winks pulls the strings with fellow new signings Alessandro Romano and Jacopo Fazzini, while Daniel Maldini and Michel Adopo support striker Paul Mendy.
Cagliari have not beaten Inter since a 2-1 home result in March 2019, followed by two draws and 11 defeats in all competition.
Cagliari vs. Inter line-ups
Cagliari: Caprile; Ze Pedro, Deiola, Rodriguez, Obert; Romano, Winks, Fazzini; Adopo, Maldini; Mendy
Inter: J Martinez; Pavard, Akanji, Bastoni; Luis Henrique, Barella, Calhanoglu, Sucic, Dimarco; Esposito, Lautaro Martinez
Player statistic
| 9′ |  |
Hakan Calhanoglu
(Assist: Nicolò Barella)
|
||
| 14′ | Manuel Akanji |
| Alessandro Deiola | 56′ | |||
| Kevin Carlos |  |
88′ |
Match statistic
Cagliari
Inter
Starting lineups
Substitutes
