Sebastiano Esposito joins little brother Pio in the XI for Italy, the first time two siblings have started for the Nazionale since 1915, but the family makes history with three brothers.
It kicks off at the Ataturk Spor Kompleski Matli Stadyumu in Bursa at 19.45 UK time (20.45 CEST).
You can follow all the build-up and action as it happens on the Liveblog.
The pressure is already on the Azzurri after their 2-0 Nations League home defeat to Belgium, so Roberto Mancini makes a massive eight changes to the side that started that match.
Esposito brothers in history books
One of the only survivors from the Stadio Olimpico loss is Pio Esposito, but he is joined in the trident attack by his big brother Sebastiano.
There have been brothers in the same Italy team before, including Simone and Pippo Inzaghi for 11 minutes in 2000 against England, but together from the start is a genuine rarity.
It has not happened since Aldo and Luigi Cevenini ran out for Italy against Switzerland in 1915, with both players who managed to get on target in a chaotic 9-4 result.
There is even more history made by the Esposito family, though, because Sebastiano completes the hat-trick.
Pio is a regular for the Azzurri and the youngest of the brothers at 21, but 25-year-old Salvatore had already made his senior Italy debut in June 2022 under coach Mancini.
Salvatore is currently in Serie B playing for Sampdoria.
Tonight is the debut for Sebastiano, who turned 24 in July and joined Sassuolo this summer.
Never before has a family of three brothers all played for Italy at senior level.
